Rambler's Top100

ФОРУМ "ТРУДНЫЕ ДЕТИ"





Форум временно законсервирован, причины смотри здесь.

Теперь доктор Лев Пережогин осуществляет бесплатные онлайн-консультации на своем персональном сайте drlev.ru



ТРУДНЫЕ ДЕТИ > ФОРУМ

... trial of fluoxetine in adolescents with major depression

 
Тема закрыта    Список форумов Трудные дети -> Обзор журналов и короткие научные сообщения
Автор Сообщение
drLev
Доктор


Зарегистрирован: 23.03.2004
Сообщения: 1483
Откуда: Москва

Добавлено: Сб Апр 25, 2009 9:04 am    Заголовок сообщения: ... trial of fluoxetine in adolescents with major depression

Addict Behav. 2009 Mar 12.

Double-blind placebo-controlled trial of fluoxetine in adolescents with comorbid major depression and an alcohol use disorder.

Cornelius JR, Bukstein OG, Wood DS, Kirisci L, Douaihy A, Clark DB.

University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh PA 15213, USA.

OBJECTIVE: This study compared the acute phase (12-week) efficacy of fluoxetine versus placebo for the treatment of the depressive symptoms and the drinking of adolescents with comorbid major depression (MDD) and an alcohol use disorder (AUD). We hypothesized that fluoxetine would demonstrate efficacy versus placebo for the treatment of both the depressive symptoms and the drinking of comorbid MDD/AUD adolescents. METHODS: We conducted the first double-blind placebo-controlled study of fluoxetine in adolescents with comorbid MDD/AUD. All participants in both treatment groups also received intensive manual-based Cognitive Behavioral Therapy (CBT) and Motivation Enhancement Therapy (MET). RESULTS: Fluoxetine was well tolerated in this treatment population. No significant group-by-time interactions were noted for any depression-related or drinking-related outcome variable. Subjects in both the fluoxetine group and the placebo group showed significant within-group improvement in both depressive symptoms and level of alcohol consumption. End-of-study levels of depression and drinking were low in both treatment groups. CONCLUSIONS: The lack of a significant between-group difference in depressive symptoms and in drinking may reflect limited medication efficacy, or may result from limited sample size or from efficacy of the CBT/MET psychotherapy. Large multi-site studies are warranted to further clarify the efficacy of SSRI medications in this adolescent MDD/AUD population.
_________________
Консультации д.м.н. Пережогина Л. О. (drLev) http://www.drlev.ru/help.php
Эта тема закрыта    Список форумов Трудные дети -> Обзор журналов и короткие научные сообщения

Rambler's Top100 Рейтинг@Mail.ru